5.4 Cytokine Crushers

In this episode, we are joined by Michael Macklin, MD, PharmD, Assistant Professor of Medicine at the University of Chicago, to discuss the teams in the Cytokine Crushers region of RheumMadness 2025, the Innovation Invitational.

This is part 1 of the conversation, where we go in depth about the long-term outcomes of anifrolumab in SLE study and give a primer about type 1/2 cytokines so you're ready to dig into the TYK2 in SLE and Oral Anti-IL23 studies.

Join us again next week for part 2 of this discussion to learn more about this region.

Links to the Cytokine Crushers Scouting Reports:

• Oral anti-IL23, by collaborating Chicago area rheumatology fellowship programs (Loyola, Northwestern, and the University of Chicago)
• Long-term outcomes of anifrolumab in SLE, by the Medical University of South Carolina (MUSC) Adult Rheumatology Fellowship
• TYK2 inhibitor in SLE, by the University of North Carolina (UNC) Adult Rheumatology Fellowship

Links to old scouting reports and other studies referenced in this podcast:

• TULIP 1/2 scouting report from RheumMadness 2021
• LLDAS scouting report from RheumMadness 2024
• Morand EF, Abreu G, Furie RA, Golder V, Tummala R. Lupus low disease activity state attainment in the phase 3 TULIP trials of anifrolumab in active systemic lupus erythematosus. Ann Rheum Dis. 2023 May;82(5):639-645. doi: 10.1136/ard-2022-222748. Epub 2023 Jan 23. Erratum in: Ann Rheum Dis. 2024 Apr 11;83(5):e12. doi: 10.1136/ard-2022-222748corr1. PMID: 36690388; PMCID: PMC10176410.
• Tanaka Y. Viewpoint on anifrolumab in patients with systemic lupus erythematosus and a high unmet need in clinical practice. RMD Open. 2023 Aug;9(3):e003270. doi: 10.1136/rmdopen-2023-003270. Erratum in: RMD Open. 2024 Apr 4;10(2):e003270corr1. doi: 10.1136/rmdopen-2023-003270corr1. PMID: 37597847; PMCID: PMC10441065.
• ORAL Surveillance scouting report from RheumMadness 2024

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Intro/outro music: Cheery Monday by Kevin MacLeod
Link: https://incompetech.filmmusic.io/song/3495-cheery-monday
License: http://creativecommons.org/licenses/by/4.0/