2.3 Cells Region

In this episode, we discuss the teams in the Cells region of the 2022 RheumMadness Tournament. Our DEI discussion topic is increasing diversity in rheumatology clinical trials.

Hosts: David Leverenz (Assistant Professor of Medicine at Duke), Guy Katz (Fellow at MGH), Michael Macklin (Resident at UPMC), Michael Cunningham (Fellow at UNC)

Learn more about RheumMadness by visiting our website: https://sites.duke.edu/rheummadness

References:
Anti-NET antibodies: Zuo Y, Yalavarthi S, Gockman K, et al. Anti-Neutrophil Extracellular Trap Antibodies and Impaired Neutrophil Extracellular Trap Degradation in Antiphospholipid Syndrome. Arthritis Rheumatol. 2020;72(12):2130-2135. doi:10.1002/art.41460

Cytokine networks: Simon Q, Grasseau A, Boudigou M, et al. A Proinflammatory Cytokine Network Profile in Th1/Type 1 Effector B Cells Delineates a Common Group of Patients in Four Systemic Autoimmune Diseases. Arthritis Rheumatol. 2021;73(8):1550-1561. doi:10.1002/art.41697

CAR-T cells (1): Mougiakakos D, Krönke G, Völkl S, et al. CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus. N Engl J Med. 2021;385(6):567-569. doi:10.1056/NEJMc2107725

CAR-T cells (2): Orvain C, Boulch M, Bousso P, Allanore Y, Avouac J. Is There a Place for Chimeric Antigen Receptor-T Cells in the Treatment of Chronic Autoimmune Rheumatic Diseases?. Arthritis Rheumatol. 2021;73(11):1954-1965. doi:10.1002/art.41812

Pim kinases: Maney NJ, Lemos H, Barron-Millar B, et al. Pim Kinases as Therapeutic Targets in Early Rheumatoid Arthritis. Arthritis Rheumatol. 2021;73(10):1820-1830. doi:10.1002/art.41744

SLE clinical trial diversity: Falasinnu T, Chaichian Y, Bass MB, Simard JF. The Representation of Gender and Race/Ethnic Groups in Randomized Clinical Trials of Individuals with Systemic Lupus Erythematosus. Curr Rheumatol Rep. 2018;20(4):20. Published 2018 Mar 17. doi:10.1007/s11926-018-0728-2

RA clinical trial diversity: Strait A, Castillo F, Choden S, et al. Demographic Characteristics of Participants in Rheumatoid Arthritis Randomized Clinical Trials: A Systematic Review. JAMA Netw Open. 2019;2(11):e1914745. Published 2019 Nov 1. doi:10.1001/jamanetworkopen.2019.14745

Critical race theory and SLE trial enrollment: Sneed RS, Mason M, Williams JN, et al. Using Critical Race Theory to Understand Trial Participation Among Black Individuals With Systemic Lupus Erythematosus: A Qualitative Study of Patients and Caregivers. Arthritis Care Res (Hoboken). 2021;73(10):1387-1395. doi:10.1002/acr.24635

Intro and Outro music:
Cheery Monday by Kevin MacLeod
Link: https://incompetech.filmmusic.io/song/3495-cheery-monday
License: http://creativecommons.org/licenses/by/4.0/